for most of this year i was working (unpaid) over 80 hours a week, mainly using blender, but also doing my share of daily chores in our flat/apartment. the latter might not be classed as work per se, but i noticed i was finding a lot more aches in my fingers and hands than previously in my life.
one of the reasons for this, other than not resting my hands enough in any given day, was my mouse just didn't seem to help with the rsi (repetitive strain injury) then my old died and i started sharing my flatmate's laptop, and using a wrist support that sits in front of the keyboard and touch pad.
a couple of months later, and i've noticed a significant decrease in my rsi type symptoms. i'm also taking more frequent, although short, breaks away from the computer.
interestingly that you mention the low profile mouses being more problematic, since a touch pad is flat, but i find my fingers seem to rest in a more natural (slightly curled) posture, when typing or using blender. i also regularly switch from using my right hand to left hand to control the mouse pointer and buttons, something i couldn't do with a conventional mouse.
anyone in teenage years or even 20's might be thinking this isn't something to be concerned about until you become much older, but it is never too early to start using more ergonomically comfortable equipment.